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RESEARCH USE ONLY. This product is intended exclusively for in vitro research and laboratory experimentation. By law, it is strictly prohibited for human or animal consumption, Injection, or administration of any kind. Handle with extreme caution.

Semax 10mg

$115.00

Product Description

Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) fragment. It is primarily studied for its nootropic and neuroprotective properties, including enhancing cognitive function, memory, and focus. Semax has also been investigated for its ability to modulate stress responses, improve cerebral blood flow, and support recovery from neurological conditions such as stroke or ischemia

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Semax is a synthetic peptide derived from a fragment of adrenocorticotropic hormone (ACTH). It was developed by Russian scientists in the 1980s and has been used in Russia and Ukraine for various neurological conditions, including stroke and cognitive disorders.

How Does Semax Work?

Semax is designed to cross the blood-brain barrier and exert its effects directly on the brain. It is believed to work through several mechanisms:

  • Neurotrophic Factor Upregulation: Semax increases levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are essential for neuronal growth and survival.
  • Neurotransmitter Modulation: It may influence the activity of neurotransmitters like dopamine, serotonin, and enkephalin, which are involved in mood, cognition, and pain perception.

Potential Benefits of Semax

  • Neuroprotection: Semax may protect neurons from damage caused by various factors, such as stroke, trauma, and neurodegenerative diseases.
  • Cognitive Enhancement: It may improve cognitive functions like memory, attention, and learning.
  • Mood Regulation: Semax may have mood-stabilizing effects by modulating neurotransmitter levels.
  • Pain Relief: It may alleviate pain by interacting with opioid receptors.

Semax has shown promise in various neurological conditions. It’s particularly recognized for its neuroprotective and neuroregenerative properties.

Neuroprotective Effects

  • Stroke: Semax has been studied in stroke patients, where it has shown potential to improve motor function, cognitive abilities, and reduce inflammation.
  • Neurodegenerative Diseases: Research suggests that Semax may be beneficial for conditions like Alzheimer’s disease and Parkinson’s disease, as it can protect neurons from damage and promote neurogenesis.
  • Brain Injury: Semax may help protect the brain from damage caused by traumatic brain injury.
  • Glaucoma: Some studies suggest that Semax may protect against pressure-induced nerve damage in glaucoma patients.

Mechanisms of Action

Semax exerts its neuroprotective effects through various mechanisms:

  • Neurotrophic Factor Upregulation: It increases levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are essential for neuronal growth and survival.
  • Neurotransmitter Modulation: Semax may influence the activity of neurotransmitters like dopamine, serotonin, and enkephalin, which are involved in mood, cognition, and pain perception.
  • Anti-inflammatory Effects: It may reduce inflammation in the brain, which can contribute to neurodegenerative diseases.
  • Improved Blood Flow: Semax may improve blood flow to the brain, providing essential nutrients and oxygen.

Future Research

While Semax has shown promising results, further research is needed to fully understand its mechanisms of action and long-term effects. Clinical trials with larger sample sizes and longer durations are necessary to confirm its efficacy and safety.

References

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  2. Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066-19077. Published 2014 Nov 19. doi:10.3390/molecules191119066
  3. Vukojevic J, Milavić M, Perović D, et al. Pentadecapeptide BPC 157 and the central nervous system. Neural Regen Res. 2022;17(3):482-487. doi:10.4103/1673-5374.320969
  4. Knezevic M, Gojkovic S, Krezic I, et al. Occlusion of the Superior Mesenteric Artery in Rats Reversed by Collateral Pathways Activation: Gastric Pentadecapeptide BPC 157 Therapy Counteracts Multiple Organ Dysfunction Syndrome; Intracranial, Portal, and Caval Hypertension; and Aortal Hypotension. Biomedicines. 2021;9(6):609. Published 2021 May 26. doi:10.3390/biomedicines9060609
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  9. Sikiric P, Drmic D, Sever M, et al. Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy. Curr Pharm Des. 2020;26(25):2991-3000. doi:10.2174/1381612826666200424180139
  10. Park JM, Lee HJ, Sikiric P, Hahm KB. BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection. Curr Pharm Des. 2020;26(25):2971-2981. doi:10.2174/1381612826666200523180301
  11. National Center for Biotechnology Information. PubChem Compound Summary for CID 9941957. https://pubchem.ncbi.nlm.nih.gov/compound/Bpc-157. Accessed Sept. 10, 2021.
  12. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83. doi: 10.2174/13816128130111. PMID: 22950504.
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